Histamine receptors

Histamine receptors are 7-transmembrane receptors which mediate cellular responses to the biogenic amine histamine. Histamine may be released as a transmitter in neuronal preparations or as a mediator of an inflammatory response by mast cells. Currently, four histamine receptors have been identified The histamine receptors are a class of G protein-coupled receptors which bind histamine as their primary endogenous ligand. There are four known histamine receptors: H 1 receptor; H 2 receptor; H 3 receptor; H 4 receptor; Compariso

Histamine Receptor - an overview ScienceDirect Topic

The histamine receptor is what determines the sensitivity, as well as the response, of the cell to histamine. Antihistamines that block the activity of histamine receptors are commonly used in sleeping aids. The four types of histamine receptors that have been identified are H 1, H 2, H 3 and H 4 receptors Histamine receptors (H1R-H4R) are characterized by their function, structure, distribution, and their affinity to histamine (36, 37). Histamine has diverse effects, both pro-inflammatory and anti-inflammatory, which are determined by both the histamine receptor subtype and the cells stimulated types

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H 1, H 2, H 3 and H 4. The histamine receptor H 2 belongs to the rhodopsin-like family of G protein-coupled receptors Histamine exerts its biological effects via four heterotrimeric guanine nucleotide-binding protein-coupled histamine receptors, H 1 to H 4, of which H 1 and H 2 receptors are most frequently..

Mast cell activation in response to viral infection

Histamine receptor - Wikipedi

  1. auf die Blutgefäße interpretiert werden. Es kontrahiert H 1 -Rezeptor-vermittelt die großen Blutgefäße (Durchmesser von mehr als 80 µm) und führt zu einer Erweiterung kleinerer Blutgefäße verbunden mit Hautrötung
  2. e H 3 receptor: Located in the central nervous system and to a lesser extent peripheral nervous system tissue Autoreceptor and heteroreceptor functions: decreased neurotransmitter release of hista
  3. e binding specific cell receptors produces clinical allergic symptoms. This mediator also activates neutrophils and eosinophils as well as being a chemoattractant for these cells. Hista

Histamin-Rezeptoren - Wikipedi

  1. e itself is a highly active agonist at the H 3 receptor. Alteration of the endogenous ligand by mono- or dimethylation of the a
  2. e and N-methylhistaprodifen are full agonists in the guinea-pig ileum, the standard assay system for H 1 receptors. In other systems, the compound may act as a partial agonists, as is the case for many hista
  3. e exerts its action via at least four distinct receptor subtypes. Molecular biological approaches have shown that all hista
  4. e exerts its effects by binding to hista

Histamin-Rezeptor - DocCheck Flexiko

Histamine is a central nervous system (CNS) neurotransmitter. It acts in the brain via three receptors, H (1), H (2), and H (3). It is a mediator of wakefulness and its activity is necessary to maintain wakefulness, alertness, and reaction time Histamine H1 Receptor NEUROCHEMICAL AND NEUROPHARMACOLOGICAL ASPECTS OF HISTAMINE RECEPTORS. JOHN E. TAYLOR, Histamine H 1 and H 2... Constitutive Activity in Receptors and Other Proteins, Part A. Saskia Nijmeijer, The histamine H 1 receptor (H... H-1 Histamine Receptor. Histamine. Histamine exerts multiple (patho)physiological actions by activating four known types of histamine receptors that are designated as H 1 -H 4, which belong to the G-protein-coupled receptor (GPCR) family and possess a multifaceted pharmacological and therapeutic profile [ 17 ] H2-histamine receptors and beta-adrenergic receptors have a number of properties in common. Stimulation of either receptor results in positive inotropic and chronotropic effects and increases in cyclic AMP and phosphorylase a. H2 and beta-adrenergic agonists will also both restore the action potential in K+-depolarized cardiac muscle Bücher bei Weltbild: Jetzt Histamine Receptors versandkostenfrei online kaufen & per Rechnung bezahlen bei Weltbild, Ihrem Bücher-Spezialisten

Histamine receptors - University of Bristo

Reports that the over-the-counter histamine H 2 receptor antagonist famotidine could help treat the novel coronavirus disease (COVID-19) appeared from April 2020. We, therefore, examined reports on interactions between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and histamine receptor antagonists The presently known histamine receptors (H 1, H 2, H 3 and H 4; Table 1) are all members of the G-protein-coupled receptor (GPCR) family (see also Hill, this issue) and they transduce extracellular signals via the G-proteins, G q, G s, G i/o and G i/o, respectively (Hough, 2001; see also Milligan & Kostenis, this issue) Purpose of review: Antihistamines exert pharmacologic effects by binding to four histamine receptors (H1-H4) at different affinities, producing variable effects depending on the receptor they predominantly bind to. This review's purpose is to determine the relative potency of antihistamines by comparing their binding affinities to these receptors. Studies on binding affinities of antihistamines to histamine receptors were reviewed and the dissociation constant for inhibitor binding (Ki.

What Is a Histamine Receptor? (with pictures

Histamine Function & Receptors Overview. In the nervous system, histamine acts as a messenger molecule or neurotransmitter. It plays key roles in the sleep-wake cycle, appetite, motivation, learning, memory, and sexual behavior [1, 5, 6]. In the stomach, histamine stimulates acid secretion. In the rest of the body, histamine intensifies the immune response, contracts smooth muscles and airways. Histamin kommt sowohl in tierischen, pflanzlichen als auch menschlichen Organismen vor. Dabei leitet sich das Wort aus dem Altgriechischen histos für Gewebe ab. Histamin ist ein Gewebshormon und Neurotransmitter. Gerade bei allergischen Reaktionen spielt Histamin beim Menschen im Immunsystem eine große Rolle Histamin ist ein biogenes Amin, das nicht nur als natürlicher Botenstoff in unserem Körper, sondern auch in verschiedenen Lebensmitteln vorkommt. Insbesondere durch Verarbeitungsprozesse, Haltbarmachung oder auch durch Reifungsprozesse steigt der Histamingehalt in verschiedenen Produkten There are 4 Histamine Receptors (H1R-H4R) which all play different roles in the body:. H1R - found in peripheral tissues, gut, smooth muscle, adrenal medulla, bronchia, blood vessels, and lymphocytes , neocortex, claustrum, hippocampal formation, posterior hypothalamus, and thalamus R. H2R - also found in peripheral tissues and the CNS, specifically gastric parietal cells, smooth muscle, and.

Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. Histamine is involved in the inflammatory response and has a central role as a mediator of itching. As part of an immune response to foreign pathogens, histamine is produced by basophils. responses of histamine receptors and their underlying signal transduction properties (e.g., localization on either the presynaptic or postsynaptic neuronal membranes). This review summarizes the most recent findings on the role of histamine and the effects mediated by the four histamine receptors in response to the various stimuli associ- ated with and promoting neuropathic pain. We. Histamine Receptors von Patrizio Blandina, Maria Beatrice Passani (ISBN 978-3-319-40308-3) online kaufen | Sofort-Download - lehmanns.d

Histamine Receptors mucosa, lung).24 Moreover, cell lines transfected with the cloned H 2 receptor genes showed an H 2 receptor-mediated increase of cAMP.35,36,37 In addition, alternative signalling pathways for the H 2 receptor have been identified. In differentiated HL-60 cells and CHO or HEPA cells transfected with the H 2 receptor cDNA, an H 2 receptor-mediated increase of the. Histamine receptors are widespread in the central nervous system and in peripheral tissues. Three types have been recognized and designated H1, H2, and H3. They differ in pharmacology, distribution, and mode of action. Entry Version RECEPT HISTAMINE Abbreviation Entry Term(s) Histamine Binding Sites Add Histamine Receptor Add Histamine Receptors Add Receptors, Histamine Add Pharm Action. Histamine Pharmacodynamics continued: Some important histamine promoted effects occur not true histamine's interaction with histamine receptors but by histamine interaction with other receptors. Many of these interactions are responsible for side effects associated with antihistamines medications. One prominent example is the side effect of sedation. The side effect is the basis for. A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors. Part of the book focuses on novel approaches to the study of histamine receptors such as polymorphism, genetic linkage, and computational analysis, and on the use of new histaminergic ligands in diseases such as asthma and dermatitis

histamine bioassayEosinophils and Cancer | Cancer Immunology Research

Histamine exerts its biological effects by binding to and activating four distinct separate rhodopsin-like G protein-coupled receptors-histamine H1 receptor, histamine H2 receptor, histamine H3 receptor, and histamine H4 receptor. Each of the histamine receptors produce a functional response, but their mechanism differs. The H1 receptor couples to Gq/11 stimulating phospholipase C, whereas the. Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues. Its physiological functions are mediated by four 7-transmembrane G protein-coupled receptors (H1R, H2R, H3R, H4R) that are all targets of pharmacological intervention. The receptors display molecular heterogeneity and constitutive activity. H1R antagonists are long known antiallergic and sedating drugs. Histamine H 3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons, and also control histamine turnover by feedback inhibition of histamine synthesis and release. The H 3 receptor has also been shown to presynaptically inhibit the release of a number of other. Histamine 2 Receptor Blockers. Mechanism of action. Blocks histamine from binding to histamine 2 receptors decreasing acid in the stomach. Patho background. Histamine 2 blockers are in the stomach. Histamine binds to these blockers and stimulates acid prodcution. Indications. Stomach ulcers. Peptic ulcer disease

Histamine Receptors - Preclinical and Clinical Aspects. Sprache: Englisch. Dateigröße in MByte: 18. (eBook pdf) - bei eBook.d H2 antagonists block histamine-induced gastric acid secretion from the parietal cells of the gastric mucosa (lining of the stomach). H2 antagonists are used to treat gastroesophageal reflux disease (), gastrointestinal ulcers and other gastrointestinal hypersecretory conditions Histamine Receptors. The differing potency of antagonists in blocking histamine action to increase the contraction rate in isolated mouse atria and gastric acid secretion or to induce smooth muscle contraction in isolated guinea pig ileum led to the first classification of histamine receptors into the H 1 and H 2 subtypes by Ash and Schild (1966), supported by the subsequent development of. dict.cc | Übersetzungen für 'histamine receptor' im Englisch-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,.

Frontiers The Role of Histamine and Histamine Receptors

A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors. Part of the book focuses on novel approaches to the study of histamine recep.. Histamine exerts its biological activity via the interaction with four distinct G protein-coupled histamine receptors. Among these histamine receptor subtypes, H1 and H2 are expressed in the hearts and kidneys, and H3 is expressed in the ending of sympathetic nerves in these tissues (32, 33)

Histamine H1 receptor. Thụ thể H1 là thụ thể histamine thuộc họ thụ thể bắt cặp với protein G giống rhodopsin. Thụ thể này được kích hoạt bởi histamine. Nó được biểu hiện ở các cơ trơn, các tế bào nội mô mạch máu, tim và hệ thần kinh trung ương. Thụ thể H 1 liên kết. The histamine receptors are a class of G protein-coupled receptors which bind histamine as their primary endogenous ligand.There are four known histamine receptors:H1 receptor,H2 receptor,H3 receptor,H4 receptor. Cat No. product name. T0031. Ziprasidone hydrochloride monohydrate Accurate characterization of the molecular mechanisms of the action of ligands is an extremely important issue for their appropriate research, pharmacological, and therapeutic uses. In view of this fact, the aim of the present work was to investigate the mechanisms involved in the actions of mepyramine at the guinea pig H1 receptor stably expressed in Chinese hamster ovary cells

The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC. The histamine H4 receptor (H4R) was first noted as a sequence in genomic databases that had features of a class A G-protein coupled receptor. This putative receptor was found to bind histamine consistent with its homology to other histamine receptors and thus became the fourth member of the histamine receptor family. Due to the previous success of drugs that target the H1 and H2 receptors, an. About Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features Press Copyright Contact us Creators. Translations in context of histamine receptors in English-French from Reverso Context: In vitro examinations of emedastine's affinity for histamine receptors (H1, H2, and H3) demonstrate 10,000-fold selectivity for the H1 receptor, Kis = 1.3 nM, 49,064 nM and 12,430 nM, respectively

Here we show that cloperastine and two other histamine H1 receptor antagonists selectively kill HeLa cisR cells at concentrations that little affect parental HeLa S cells. The sensitivity of HeLa. Buy Histamine Receptor Activators from Santa Cruz. These activate Histamine Receptor and may affect a variety of other inflammation and immune response related proteins

Since their discovery, the potential of histamine H3 receptor ligands in various CNS disorders have received much attention. This resource presents recent advances with an emphasis on pharmacology Translations in context of histamine receptor in English-French from Reverso Context: The present invention provides a novel use of policosanol as a histamine receptor antagonist dict.cc | Übersetzungen für 'histamine receptors' im Englisch-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,.

Histamine H2 receptor - Wikipedi

  1. e exerts its effects by binding to its 4 receptors [hista
  2. e H1 Receptor Activators from Santa Cruz. These activate Hista
  3. e receptor antagonists, although developed many decades ago, are still effective for the treatment of allergic and gastric acid-related conditions. This article focuses on novel aspects of the pharmacology and molecular mechanisms of hista
  4. e H3 and H4 receptors : synthesis, pharmacological evaluation, and cross-target QSAR studies Vol. 17, No. 11 (2009), p. 3987-9
  5. e H 1 Receptor (HRH1) Antibody (#AHR-001) is a highly specific antibody directed against an epitope of rat H1R. The antibody can be used in western blot, immunocytochemistry, indirect flow cytometry, and immunohistochemstry applications. It has been designed to recognize H1R from rat, mouse, and human samples
  6. 142703 - HISTAMINE RECEPTOR H2; HRH2 - HRH2 Jutel et al. (2001) noted that HRH1 or HRH2 deletions are reported to result in abnormalities in the central nervous and gastrointestinal systems. Mice lacking Hrh1 have lower, whereas Hrh2-deficient mice have higher, percentages of Ifng ()-producing cells, compared to wildtype mice

Histamine H1 and H2 receptors are essential transducers of

dict.cc | Übersetzungen für 'histamine receptors' im Deutsch-Bulgarisch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,. dict.cc | Übersetzungen für 'histamine receptors' im Deutsch-Dänisch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,. There are several splice variants of H 3 present in various species. Though all of the receptors are 7-transmembrane g protein coupled receptors, H 1 and H 2 are quite different from H 3 and H 4 in their activities. H 1 causes an increase in phosphoinositol hydrolysis, H2 stimulates gastric acid secretion, and H3 mediates feedback inhibition of histamine Histamine Receptors von Patrizio Blandina, Maria Beatrice Passani (ISBN 978-3-319-40308-3) online kaufen | Sofort-Download - lehmanns.d Histamine Receptor and diseases. Histamine plays an important role in the development of inflammation, neurology and cancer. Meanwhile it has important physiological functions in controlling gastric mucosa, allergic diseases, and regulating sleep revival cycle and so on. Histamine has also been shown to be involved in cell proliferation, embryo development and tumor growth. In terms of the.

II. Histamine H 1-Receptor A. Distribution and Function. The study of the distribution of histamine H 1-receptors in different mammalian tissues has been greatly aided by the development of selective radioligands for this particular histamine receptor subtype.[3 H]mepyramine was originally developed in 1977 (Hill et al., 1977) and since that time has been used successfully to detect H 1. Histamine receptors could represent the target for compounds, which, taking advantage of noncholinergic mechanisms potentiate cholinergic functions, and may produce beneficial effects on disorders in which the cholinergic function is compromised. Yet, ACh/histamine interactions are complex and multifaceted. Histamin ist ein Eiweiß, das sowohl in tierischen als auch pflanzlichen Nahrungsmitteln vorkommt. Es wird aber auch gezielt zur Reifung oder Herstellung von bestimmten Lebensmitteln - wie beispielsweise geräucherten Wurstwaren, bestimmte Käsesorten, Sauerkraut und Bier - eingesetzt. Mit zunehmender Lagerdauer steigt der Histamingehalt nochmals an. Im Körper selbst wird Histamin. Anti-Histamine H 2 Receptor (HRH2) (extracellular) Antibody (#AHR-002) can be used in western blot, indirect flow cytometry, immunohistochemistry, and immunocytochemistry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting the receptor in living cells. It has been designed to recognize H2R from rat and mouse samples. It will not recognize human H2R.

struggling to get histamine symptoms under control? Tired of scouring the internet for answers? If you've tried every dietary approach, only to be disappointed time and again, this step-by-step program is for you. you'll learn all about histamine from a to z, reclaim your life, feel (and look) better than ever. The program features a 7 day ultra low histamine vegan meal plan, plus a 7 day. All histamine receptors, H1R-H4R, have excitatory actions on enteric neurons and are found in the whole intestine and enteric nervous system in humans . Elevated levels of H1Rs and H2Rs are found in endoscopic biopsies from humans with food allergy and irritable bowel syndrome . B. Immune System . Histamine plays a central role in innate and acquired immunity: in allergy and inflammation. Histamine is a pleiotropic mediator involved in a broad spectrum of (patho)-physiological processes, one of which is the regulation of inflammation. Compounds acting on three out of the four known histamine receptors are approved for clinical use. These approved compounds comprise histamine H1-receptor (H1R) antagonists, which are used to control allergic inflammation, antagonists at H2R.

Mast Cell - YouTube

Histamin - Wikipedi

1. Histamine Histidine Histamine histidine decarboxylase 2. Non-mast cell sites epidermis, gastric mucosa, neurons within the CNS granules of MAST cells 3. mediator of allergy, inflammation, gastric acid secretion 4. Histamine receptors GPCRs H1 receptor -IP3 ,DAG ↑ -bronchoconstriction -Vasodilation via NO -Brain , Ganglia 5 Histamine Receptors jetzt im Weltbild Bücher Shop versandkostenfrei bestellen. Gleich reinklicken und zudem tolle Bücher-Highlights entdecken! Wir verwenden Cookies, die für die ordnungsgemäße Bereitstellung unseres Webseitenangebots zwingend erforderlich sind. Mit Klick auf Einverstanden setzen wir zusätzlich Cookies und Dienste von Drittanbietern ein, um unser Angebot durch Analyse.

Histamine - Wikipedi

Stimulation with histamine is known to enhance accumulation of inositol phosphates and elevate intracellular Ca 2+ concentration in different cell types. 2,38 Four subtypes of surface receptors are known to mediate responses to histamine, all of which are G protein-coupled receptors. 39 As already described in the literature, 40 only mRNAs for H1 and H2 receptors are present in EA.hy926 and. Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by 3 pharmacologically defined receptors termed the H1, H2 (HRH2; 142703), and H3 (HRH3; 604525) receptors.The H1 receptor was the first member of this family to be pharmacologically defined with the design of selective antagonists, the. All the histamine receptor subtypes belong to the class A rhodopsin-like G protein-coupled receptors (GPCRs) and have been named histamine H1-receptor (H 1 R), H 2 R, H 3 R, and H 4 R in order of their discovery. While H 1 R and H 2 R are ubiquitously expressed and bind histamine with relatively low potency (pEC50 ~6), the expression of high potency (pEC50 ~8) histamine receptor subtypes H 3 R. Histamine Receptors are a class of G protein-coupled receptors with histamine as their endogenous ligand. There are four known histamine receptors: H1 receptor, H2 receptor, H3 receptor, H4 receptor. The H1 receptor is a histamine receptor belonging to the family of Rhodopsin-like G-protein-coupled receptors. This receptor, which is activated by the biogenic amine histamine, is expressed.

Roles of histamine and its receptors in allergic and

Histamine H 4 receptor couples to G i /G 0 proteins and receptor activation leads to inhibition of adenylate cyclase, mobilisation of calcium from intracellular stores and activation of the mitogen-activated protein kinase (MAPK) cascade. 1,2. Histamine H 4 receptor is largely expressed in haemopoietic cells including mast cells, eosinophils, dendritic cells and T lymphocytes Lesen Sie Histamine and Histamine Receptors in Health and Disease von erhältlich bei Rakuten Kobo. This book provides a comprehensive overview on current histamine and histamine receptor research in context of human hea.. Histamine is an organic nitrogen compound, acts on target cells in mammalian brain via stimulation of Histamine 1/2. Histamine suppresses the generation of ROS through the Histaminetype-2 receptor (H2 receptor). [1] Histamine inhibits the generation and release of reactive oxygen species (ROS) by monocytes/macrophages (MO) during respiratory burst Anti-Histamine Receptor 4 Antibody, CT Anti-Histamine Receptor 4 Antibody, C-terminus detects level of Histamine Receptor 4 & has been published & validated for use in ELISA & WB. - Find MSDS or SDS, a COA, data sheets and more information

A Review of Histamine Receptors - News Medica

  1. e receptors' im Latein-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,.
  2. e Receptors and Cyclic Nucleotides 5. Hista
  3. e receptors' im Ungarisch-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,.
  4. e receptors play important roles in various pathophysiological conditions and are effective targets for anti-allergy treatment, however the mechanism of receptor activation remain elusive. Here, we present the cryo-electron microscopy (cryo-EM) structure of the human H 1 R in complex with a G q protein in an active conformation via a NanoBiT tethering strategy.
  5. e receptors' im Rumänisch-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,.

Histamine Receptors - sigmaaldrich

dict.cc | Übersetzungen für 'histamine receptors' im Isländisch-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,. dict.cc | Übersetzungen für 'histamine receptors' im Kroatisch-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,. dict.cc | Übersetzungen für 'histamine receptors' im Türkisch-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,. dict.cc | Übersetzungen für 'histamine receptors' im Schwedisch-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,. dict.cc | Übersetzungen für 'histamine receptors' im Spanisch-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,.

AUTACOIDGastrin - Wikipedia

Histamine Receptors Sigma-Aldric

  1. e receptors' im Finnisch-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,.
  2. e receptors' im Norwegisch-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,.
  3. e receptors' im Italienisch-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,.
  4. e receptors' im Deutsch-Tschechisch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,.
  5. e receptors' im Slowakisch-Deutsch-Wörterbuch, mit echten Sprachaufnahmen, Illustrationen, Beugungsformen,.
  6. Histamine Mechanism - Medica
  7. Histamine, antihistamines, and the central nervous syste
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